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Research in Pharmacy |
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Therapeutic potential of selenium and glutathione peroxidase
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The selenium and glutathione
peroxidase projects involved development of a novel analytical
technique to measure both total plasma selenium by ICP-MS as
well as selenoprotein P (the major selenium containing protein
in plasma) using SDS-PAGE (polyacrylamide gel electrophoresis).
Selenium is thought to have many beneficial health effects including
protection against cardiovascular disease and cancer and previous
limited work has indicated that Tasmanians may be deficient.
A population assessment of selenium status in over 335 Southern
Tasmanians was conducted in 2003 and 2004, the results of which
are to be submitted for publication in July/August 2005. |
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Brazil nuts - a source of selenium |
Selected
publications:
Jacobson GA, Featherstone AM, Townsend AT, Lord R, Peterson
GM.. Selenoprotein P analysis in human plasma: a discrepancy
between HPLC fractionation of human plasma with heparin affinity
chromatography and SDS-PAGE with immunoblot analysis. Biol Trace
Elem Res (in press)
Featherstone AM, Townsend AT, Jacobson GA, Peterson GM, ŒComparison
of methods for the determination of total selenium in plasma
by magnetic sector inductively coupled plasma mass spectrometry¹,
Anal Chim Acta 512 319-327 (2004) |
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Glutathione peroxidase is a selenium containing major antioxidant
enzyme.
Levels and the relationship with plasma selenium have also been
investigated
in 170 Tasmanians, as well as in patients with acute severe
asthma,
rheumatoid arthritis and osteoarthritis. |
Townsend A, Featherstone A,
Chery C, Vanhaecke F, Kirby J, Krikowa F, Maher B, Jacobson
G, Peterson G, Increased selenium concentrations in Seronorm
Trace Elements Serum (Level 2) Clin Chem 50 (8) 1481-1482
(2004)
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For further information see Glenn
Jacobson
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